Approval was based on a study of 80 patients with relapsed or refractory DLBCL randomly assigned to receive either Polivy with bendamustine and rituximab or bendamustine and rituximab alone.

Researchers found a complete response rate of 40 percent with Polivy plus bendamustine and rituximab compared with 18 percent with bendamustine and rituximab alone. Twenty-five patients achieved a partial or complete response with Polivy plus bendamustine and rituximab; 64 percent of these patients had a duration of response of six months or longer and 48 percent achieved a duration of response of at least one year.
The most commonly reported side effects of the combination of Polivy plus bendamustine and rituximab included neutropenia, thrombocytopenia, anemia, peripheral neuropathy, fatigue, diarrhea, fever, decreased appetite, and pneumonia.
Patients should be closely monitored for infusion-related reactions, low blood counts, fatal or serious infections, tumor lysis syndrome, hepatotoxicity, and progressive multifocal leukoencephalopathy. The FDA noted that women of reproductive age should be advised to use effective contraception during treatment and for three months following the last dose, and those who are pregnant or breastfeeding should not be treated with Polivy.
Approval of Polivy was granted to Genentech.

A healthy diet may trigger a better response to a certain kind of melanoma treatment. How?

New research suggests that a diet that's full of fiber appears to lead to more diverse intestinal bacteria (microbiome). In turn, a thriving gut microbiome is linked to a stronger response to an immune therapy for the aggressive skin cancer. "We found that patients eating a high-fiber diet at the start of therapy were about five times more likely to respond to the anti-PD-1 immunotherapy," said study author Christine Spencer. She's a research scientist with the Parker Institute for Cancer Immunotherapy in San Francisco. Anti-PD-1 immunotherapy helps the immune system recognize cancer cells as dangerous cells that need to be destroyed, according to the American Cancer Society (ACS). The cancer drugs Keytruda and Opdivo are examples of this type of immunotherapy. Melanoma is a type of skin cancer. It only accounts for about 1 percent of all skin cancers, but is responsible for most skin cancer deaths, the ACS says. Several recent studies have suggested that a

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A natural treatment for ED?

Erectile dysfunction — the inability to get and keep an erection firm enough for sex — is a common problem. You've likely seen advertisements for erectile dysfunction herbs or supplements to "increase your sexual performance." Could they work for you? Erectile dysfunction supplements and other natural remedies have long been used in Chinese, African and other cultures. But unlike prescription medications for erectile dysfunction, such as sildenafil (Viagra), vardenafil (Levitra, Staxyn), tadalafil (Cialis, Adcirca) and avanafil (Stendra), erectile dysfunction herbs and supplements haven't been well-studied or tested. Some can cause side effects or interact with other medications. And the amount of the active ingredient can vary greatly from product to product. Here's a guide to erectile dysfunction herbs and supplements: DHEA Some evidence shows that dehydroepiandrosterone (DHEA) increases libido in women and helps erectile dysfunction in men. DHEA app

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Men who are victims of domestic violence find it hard to get help and the support they need, British researchers report.

"While both men and women are reluctant to seek professional help for their abuse, there is an added barrier for men voiced in these studies, that they may be falsely accused of being the perpetrator. The men also raised wider concerns about masculinity," said study co-author Dr. Gene Feder, a professor of primary care at the University of Bristol. He and his colleagues reviewed studies of men in heterosexual and gay relationships. They found that fears of not being believed or being accused of abuse were factors in not seeking help. Embarrassment and feeling "less of a man" were reported to be other barriers. Men also worried about their partner and damaging their relationship as well as losing contact with their children. Still others were afraid of telling their family or friends, or getting professional help. Many men didn't know that professional help was available, the study found, or thought that support services were for women only. Some men

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